Vitamin D and asthma Gianenrico Senna 1, Fabiana Furci 2 1 Integrated Medicine Department, Combined University Hospital of Verona; 2 Postgraduate School of Allergology and Clinical Immunology of Messina DOI 10.30455/2611-2876-2020-5e. For instance, it acts to stimulate the immune system against various infections, such as tuberculosis and may help prevent certain types of cancer, or even autoimmune diseases like multiple sclerosis (although, this is all still being studied). Study Links Vitamin D Deficiency and Asthma Severity. Low Vitamin D levels in utero and/or early on in life has been associated with increased risk of developing asthma. PA: (215) 569-1111  NJ: (856) 235-8282, Center City Philadelphia • Society Hill Philadelphia • Northeast Philadelphia, Mt. WebMD does not provide medical advice, diagnosis or treatment. Overall, the ability to control asthma did not differ between a study group that received vitamin D supplements and a group that received placebo, according to new research at Washington University School of Medicine in St. Louis. Vitamin D is known as the sunshine vitamin. Michael Holick, MD, PhD, professor of medicine, physiology, and biophysics, Boston University School of Medicine, Boston. It is one of the vital vitamins for bone health. References. Adding vitamin D to asthma treatment to improve breathing only appears to benefit patients who achieve sufficient levels of the supplement in the blood. Interventions: Oral vitamin D3 (100,000 IU once, then 4000 IU/d for 28 weeks; n = 201) or placebo (n = 207) was added to inhaled ciclesonide (320 µg/d). Working with each patient individually, our asthma specialists can create a personalized asthma treatment plan to propel our patients forward. The average number of attacks per person per year went down from 0.44 to 0.28 with vitamin D (high-quality evidence). "Recent studies suggest that it will reduce risk of wheezing disorders, including asthma," he says. Asthma is a complex respiratory disorder of inflammatory origin, whose onset and progression are influenced by numerous elements, such as genetic, … Pia Hauk, MD, assistant professor of pediatrics, National Jewish Health, Denver. We did subgroup analyses to investigate whether the effects of vitamin D supplementation on rate of asthma exacerbations requiring treatment with systemic corticosteroids differed according to baseline vitamin D status, age, ethnic or racial origin, body-mass index, administration of bolus-dose vitamin D, amount of vitamin D administered, and concomitant use of inhaled corticosteroids . The findings appear in the September issue of the Annals of Allergy, Asthma & Immunology. "There is a lot of circumstantial evidence, but we need to do definitive studies with vitamin D interventions to see what happens.". This is important to many parents, she says. Objectives The objective of this systematic review and meta-analysis was to evaluate the efficacy and safety of vitamin D supplementation as a treatment or adjunct treatment for asthma. In the pathophysiology of asthma, vitamin D can impact the levels of specific immune cells and can also decreas… These studies will provide definitive answers on the role that this vitamin has in asthma treatment, she says. D levels with asthma and with the severity of asthma were evaluated. Because most published epidemiologic studies of vitamin D and asthma or asthma morbidity are observational, a recommendation for or against vitamin D supplementation as preventive or secondary treatment for asthma is not advisable and must await results of ongoing clinical trials. Vitamin D in children and adults has been linked to lowering the risk of asthma attacks. The study Cochrane reports that vitamin D supplements halve the risk of serious attacks when used alongside normal asthma treatment. Often, people intake vitamin D by consuming fortified foods as well as supplements because the typical diet does not contain enough food that is perfect sources of vitamin D for achieving sufficient levels. Vitamin D supplementation may improve asthma control by blocking the cascade of inflammation-causing proteins in the lung, as well as increasing production of the protein interleukin-10, which has anti-inflammatory effects, the study authors suggest. Hauk routinely tests vitamin D levels in her patients. A new study published yesterday in The Lancet Respiratory Medicine journal concluded that Vitamin D shows promise as a safe and effective treatment for asthma. Could Vitamin D deficiency be playing a role in your symptoms of coughing, wheezing, shortness of breath and/or flares of asthma? In this study, the associations of 25(OH) vit. With advanced in-office diagnostics, our asthma specialists are trained to correctly diagnosis and treat symptoms that otherwise limit comfort and health. Several researches have reported positive associations between vitamin D and asthma. There is increasing interest in the therapeutic utility of vitamin D in asthma, which is supported by a significant body of evidence on epidemiologic associations between vitamin D insufficiency and worse asthma control. How the Study Was Made The researchers took 100 patients within a private Pakistan medical practice aged 18 to 50 years and diagnosed with bronchial asthma. Vitamin D itself could prevent asthma, it might be helpful to boost levels of this vitamin if you have breathing problems. Should you take Vitamin D supplements (are you a candidate to try this new treatment approach)? The current laboratory study suggests that vitamin D can reduce white blood cell production of an inflammatory molecule implicated in asthma. Doing so is more likely to cause vitamin D toxicity, characterized by nausea, vomiting, constipation, excessive thirst and urination, and the development of kidney stones. © 2005 - 2019 WebMD LLC. On the other hand, others have reported contrasting effects of vitamin D on asthma. The health information contained in this article is meant for basic informational purposes only.  It is not intended to serve as medical advice, substitute for a doctor’s appointment or to be used for diagnosing or treating a disease. What are the best choices for treatment with Vitamin D supplements. Taking excessive doses of vitamin D in an effort to treat asthma is unadvised. Vitamin C — There’s a great deal of research that supports the use of Vitamin C as a treatment of asthma, especially against exercise-induced asthma. Further research is needed to assess long-term efficacy and safety. But "new research suggests that if we normalize vitamin D levels, you may need less medication to get control of the inflammation.". Importance There is growing evidence that vitamin D plays a role in the pathogenesis of asthma but it is unclear whether supplementation during childhood may improve asthma outcomes. "Vitamin D ... has effects on many immune cells and we are learning more and more about the impact that it can have on allergic diseases such as asthma," says Pia Hauk, MD, an assistant professor of Pediatrics at National Jewish Health in Denver. Vitamin D serves multiple important functions in the immune system. Spending even a few minutes outdoors in the sun can increase your vitamin D. Sources of vitamin D – sunshine, salmon "If you have low vitamin D levels, your asthma may be worse and you may have to take more medication to control it," she says. "If it is low, I will put them on a supplement and check the levels again after three months," she tells WebMD. Vitamin D is actually a fat-soluble hormone. Despite extensive study on asthma the association between 25-Hydroxy Vitamin D (25(OH) vit. Universally, asthma has high prevalence rates and this has led numerous studies done into its causes. The Institute of Medicine is considering whether to raise its guidelines for vitamin D intake. In support of a causal relationship, vitamin D beneficially modulates diverse immunologic pathways in heterogeneous asthma endotypes, regulating the … The current guidelines call for 200 IU/day. "The next step is to conduct a study where people with asthma who have low levels of vitamin D are treated with supplements, and then study their lung function, steroid use, and asthma exacerbations once their vitamin D levels are normal," she says. EVIDENCE SUMMARY. The board-certified physicians at The Asthma Center are Delaware Valley’s leading experts on treating patients with asthma. All rights reserved. A number of studies link its deficiency to a host of medical conditions, including heart disease, diabetes, and certain cancers. Vitamin D is a fat-soluble vitamin, which is usually present in milk products. Now, a new review article makes the case for vitamin D supplementation in the treatment of asthma. We do know that most every participant was deficient at the start and after an adequate dose of vitamin D to change their level a change in FEV1 was noticed at 2 months. The Asthma Center’s Dr. Marc Goldstein reviews this groundbreaking research and what it means for you. If asthma control was achieved after 12 weeks, ciclesonide was tapered to 160 µg/d for 8 weeks, then to 80 … Among the many health issues associated with this diet-induced condition, osteoporosis, rickets, cardiovascular disease, cancer […] Vitamin D is often called "the sunshine vitamin" because our bodies make it when we are exposed to sunlight. Taking Vitamin D was linked with needing less glucocorticosteroids following an asthma attack (either injection or tablet form). However, no study has examined the relationship between vitamin D levels and exercise-induced bronchoconstriction in asthmatic children. If these new conclusions are reproduced in larger studies, Vitamin D may be an inexpensive and safe over-the-counter (OTC) supplement that may improve asthma severity, improve treatment responsiveness and reduce asthma exacerbations. Should you be tested for Vitamin D deficiency? Vitamin D. Among its wide array of benefits include boosting lung function when it starts to decline, such as preventing the lungs from shrinking or narrowing its passages over time. Vitamin D – Getting enough vitamin D may help reduce the number of asthma attacks in children ages 6 to 15, according to the Vitamin D Council. Food sources include fish, eggs, and dairy products. It also boosts general immune health and calcitriol, which is the most common form of vitamin D … reduced response to glucocorticosteroids. They also found that vitamin D did not improve lung function or day-to-day asthma symptoms, and that it did not increase the risk of side effects at the doses that were tested. Sept 10, 2010 -- Vitamin D is the new "it" vitamin. Thomas B. Casale, MD, professor of medicine; chair, allergy and immunology, Creighton University, Omaha. Conclusion Among adults with asthma and vitamin D deficiency, supplementation with weekly oral calcifediol compared with placebo improved asthma control over 6 months. "Many parents are very concerned about side effects of inhaled steroids and would be very happy to get away with less medication," she says. For questions or media inquiries, please email Gaille at gwoodlyn@asthmacenter.com. It is also added to multivitamins and milk. Vitamin D, also known as the “sunshine vitamin” because the sun stimulates the skin to make vitamin D, has been known for years to be important in bone health. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, The Truth About Vitamin D’s Health Benefits, Food Science for Your Heart: Functional Foods, The Truth About Vitamin D: Drug Interactions. Risk factors for vitamin D deficiency include obesity, being African-American, and living in Westernized countries, the researchers report. Vitamin D toxicity is usually a … ©2020 THE ASTHMA CENTER, ALL RIGHTS RESERVED. Patients whose Vitamin D levels were “low” at the beginning of the study experienced the greatest benefit from taking Vitamin D supplements.  For these patients, their use of glucocorticosteroids with asthma flares decreased by more than half (55%). These results were obtained from cells in the laboratory, and further research will be needed to determine whether this effect will also be seen if people with asthma are given vitamin D. While the results perhaps give a reason to investigate vitamin D further, not all treatments showing initially positive results in laboratory studies go on to have a positive effect on real-… The answer is vitamin D. 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